Brain Fuel provides a space for PhD students and PostDocs of the Paris Brain Institute to present their most recent data. The goal of this internal event is to exchange feedback between speakers and experts within the Institute's community.
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May 30th @ 12 pm — Sophie Skriabine
Organisation, Development and Plasticity of the Cerebral Vasculature
Archive of Previous Brain Fuels
September 28th 2022 — Ulku Cuhadar
Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission
I developed novel optical tools to visualize in firing synapses the molecular behavior of a particular secreted trans-synaptic protein, LGI1, and its presynaptic receptor, ADAM23. I found that LGI1 in synapses was not secreted, as described elsewhere, but exo- and endocytosed through its interaction with ADAM23. Activity-driven translocation of LGI1 facilitated the formation of trans-synaptic connections proportionally to the history of activity of the synapse, modulating excitatory transmission. My findings reveal that LGI1 abundance at the synaptic cleft can be acutely remodeled and serves as a critical point of activity-dependent control of synaptic function.
Join-us on the 28/09 @ 12 pm in room 1-2 at the Paris Brain Institute.